Monday, May 14, 2012

Can we educate physicians to be more human?

By Brooke Holmes, Special to CNN Editor’s note: Brooke Holmes teaches the history of medicine and Greek literature at Princeton University. She writes with The Op-Ed Project . http://schoolsofthought.blogs.cnn.com/2012/05/14/my-view-can-we-educate-future-physicians-to-be-more-human/?hpt=hp_bn5 "For all the strides we’ve made through technological innovation, medicine is failing at the very human art of treating patients. Doctors are ill-equipped to deal with factors like diet and poverty, which are now responsible for over half the cases of premature disease and death in the United States. Armed with state-of-the art drugs and machines, they don’t always consider whether using these resources will cause more harm than good. In many cases, it no longer makes much sense to call what physicians and patients have a “relationship” at all." "Let’s back up and ask an even more fundamental question: What do we want from our doctors? In a word: communication." "Right now we inhabit a paradox. We tell pre-med students they need to focus on the sciences and then we complain that the doctors they become don’t treat us like people. If we want to improve the quality of health care, we need to be educating future physicians to think qualitatively and quantitatively, humanistically and scientifically."

Wednesday, May 9, 2012

Yet another overpriced MLM "miracle" product

Just got approached yesterday to buy waaaaay overpriced Cordyceps & ginseng pills (Nuskin's new product) - RM4500 per month's supply. Buy 10, get 2 free to boot - a RM45K investment - I could use this as a down payment for a car or piece of property (OK, outside Klang Valley)! I'm very open-minded & a supporter of traditional Chinese medicine, where it's due, but it's a fact that these MLM companies always overprice their products & the downliners always misrepresent their products. The Taiwanese (the upline of my gullible friend who can ill-afford such products but looking for a business opportunity) used the classic MLM tricks to pull wool over my eyes: 1. 1st thing was misrepresenting the product as being developed by & endorsed by Stanford University. The fine print of their website says "No". They only plan to approach Stanford U to conduct clinical trials on their product. 2. She used a listing of the product in Physician's Desk Reference as a rubber stamp approval by FDA to treat a long list of diseases. Fact #1 - their product is a food supplement & does not require FDA approval to market it Fact #2 - a listing in PDR in no way implies a drug or substance is FDA-approved. It only means it is available for sale in USA. Fact #3 - food supplements are not permitted to make medical claims of treating anything & of course, the Nuskin upline went on & on about miracle cures of impotence, look 15 years younger in 1 month, blah, blah, blah. I think the only thing she didn't cover was cancer & maybe because she knew she was talking to a doctor. 3. Thousands of rich people including movie stars are using the product & giving it "free endorsement" so why should they when they are already so rich? Well, that's why they are so rich - they are top of the heap of the MLM scheme & even M'sian downliners are subservient to S'pore upliners in Nuskin! 4. When she sensed she was losing me, she went on to say she is promoting this product only because she wants to spread the good word about the positive benefits & "Look at me, I'm 50 & look so good" - yeah, with the thickest layer of makeup. I responded & told her to look at me, I'm 44, no makeup on & I don't spend RM4500 every month on health supplements. The meeting ended pretty soon after that. Take home message: If you're already a Nuskin member, think about whether it makes sense to buy overpriced Chinese herbs from an MLM company when you can buy them from your local trustworthy Chinese medicine shop. If you aren't already a Nuskin member, think about whether it makes sense to buy overpriced Chinese herbs so you can make money off your friends for the business opportunity. So many MLM schemes in the past - Bioyoung, Lampberger (their therapeutic "medicinal" fragrance oils from France were eventually found to be sourced from China), Herbalife (Yes, I got sucked in by a relative - the only benefit I got from my experience with this MLM scheme was learning to eat less & more healthily which kickstarted my journey to healthy weight loss)...- have come & gone. They're here to stay, despite what I say (kinda like corruption in Malaysia) but that's my 2 cents worth...

Friday, April 13, 2012

FDA Announces Safety Label Changes to Finasteride

April 12, 2012 — The product labels for finasteride 1 mg (Propecia) and finasteride 5 mg (Proscar) from Merck & Co are being revised to note that some sexual adverse effects may continue after the drugs are discontinued, the US Food and Drug Administration (FDA) announced April 11.

The new label changes include:

* a revision to the Propecia label to include libido disorders, ejaculation disorders, and orgasm disorders that continued after discontinuation of the drug,
* a revision to the Proscar label to include decreased libido that continued after discontinuation of the drug, and
* a revision to both the Propecia and Proscar labels to include a description of reports of male infertility and/or poor semen quality that normalized or improved after drug discontinuation.

In 2011, both Proscar and Propecia's labels were revised to include erectile dysfunction that continued after drug discontinuation.

The FDA approved finasteride 5 mg in 1992 to treat benign prostatic hyperplasia and finasteride 1 mg in 1997 to treat androgenic alopecia in men. Finasteride 1 mg is also used off-label to treat unwanted facial hair in women. It has also been studied for chemoprevention of prostate cancer and is used off-label for this, but this use has not been approved by the FDA.

Adverse Event Reports Prompt Action

The FDA notes that sexual adverse effects were reported by patients during clinical trials of finasteride, a 5-alpha reductase inhibitor, and that this information was included in the drug's labels at the time of approval. In clinical trials, these adverse effects resolved in patients who stopped taking finasteride, as well as in most patients who continued therapy.
Finasteride (Propecia, Proscar)

For finasteride 1 mg, the FDA reviewed 421 postmarketing reports of sexual dysfunction submitted to the agency's Adverse Events Reporting System database between 1998 and 2011. Of these, 59 cases reported sexual dysfunction that lasted for at least 3 months after discontinuation of the drug, and included erectile dysfunction, decreased libido, problems with ejaculation, and orgasm disorders.

For finasteride 5 mg, the FDA reviewed 131 cases of erectile dysfunction and 68 cases of decreased libido associated with the drug that were submitted to the drug sponsor's global safety database between 1992 and 2010. Where information was available, these reported events of erectile dysfunction and decreased libido lasted for at least several weeks after drug discontinuation, the FDA says.

"Despite the fact that clear causal links between finasteride (Propecia and Proscar) and sexual adverse events have NOT been established, the cases suggest a broader range of adverse effects than previously reported in patients taking these drugs," the FDA notes in a statement. "Information about these adverse events may be important to individual patients. Therefore, prescribers and patients need to be aware of them, as part of a discussion of risk and benefits of finasteride when determining the best treatment options," the statement continued.

The agency notes that in controlled clinical trials of finasteride 1 mg, 36 (3.8%) of 945 men reported 1 or more adverse sexual experiences compared with 20 (2.1%) of 934 men who received placebo.

Sexual adverse events associated with finasteride 5 mg surfaced in 2 clinical trials. In 1 trial, these events were reported more frequently during the first year of treatment compared with in men who received placebo. In years 2, 3, and 4 of the trial, there was no significant difference between treatment groups in the incidences of impotence, decreased libido, and ejaculation disorder, the FDA says.

Friday, March 16, 2012

Botulinum to Relax Frown Lines Relieves Major Depression

From Medscape Medical News
Daniel M. Keller, PhD

March 13, 2012 (Prague, Czech Republic) — For patients with chronic major depression that does not sufficiently respond to other treatments, a single injection of botulinum neurotoxin into the glabellar muscle of the forehead to relieve frown lines appears to lead to strong and sustained improvement of the depression.

Tillmann Kruger, MD, Associate Professor in the Department of Psychiatry, Social Psychiatry and Psychotherapy at Hannover Medical School in Hannover, Germany, reported here at the 20th European Congress of Psychiatry that these findings support the concept that facial musculature not only expresses mood states but also affects mood.

He explained that frowning expresses negative emotions such as anger, fear, or sadness. A facial feedback hypothesis says that the frown itself reinforces negative emotions, with the implication that suppressing frowning will help to relieve the negative emotions.

"The theory is pretty old, and it says that many or most of the emotions we have develop somewhere in the brain, and some of them are expressed in your face, for example...and this is again received and sent back to the central nervous system by this proprioceptive feedback," he told Medscape Medical News. He said that in some cases of depression, there are signs of increased glabellar muscle activity.

Facial Feedback Theory

"Not all glabellar frown lines have to disappear to guarantee a good psychological effect," Dr. Kruger said, and full remissions have been observed in patients with residual frown lines.

"We think, regarding possible mechanisms, that the reduced proprioceptive feedback — the facial feedback theory — is the most important one. I think this is something that works 24 hours per day," he added.

There may also be some effect of social feedback in that friends and family may tell patients that they do not look so angry.

Dr. Kruger said that botulinum is able to travel in a retrograde direction via nerve fibers to the central nervous system, but given the small amount of drug used, he thought this mechanism would not explain the effects seen.

However, when asked whether a more appropriate control than placebo injections would be botulinum injections into a cranial muscle that did not affect frowning, he agreed that such a procedure would be a good control for a possible effect of botulinum not related to the relief of frown lines. Therefore, it is still possible that botulinum acted through a mechanism other than relief of frown lines.

Dr. Kruger said the study also showed that botulinum injections had excellent safety and tolerability. "It may be even economic because it's only a single injection [session], and it works for more than 16 weeks, as we have seen," he said, but the study needs to be validated in larger trials.

At present, botulinum is not indicated for treatment of depression. "But Botox has an indication to treat glabellar frown lines...and if someone has frown lines and has a depression and says, 'I want to have them away, these frown lines,' you can, of course, use it," Dr. Kruger noted.

Tuesday, February 14, 2012

Top lipstick brands carry highest lead levels

From www.theage.com.au

Four hundred of the most popular lipsticks in the US contained trace levels of lead when tested recently, confirming similar results of earlier analyses but on a much wider scale and at higher levels than previously detected.
Five L'Oreal and Maybelline lipsticks, owned by L'Oreal USA, ranked among the top 10 most contaminated brands, according to the analysis by the Food and Drug Administration. Two Cover Girl and two NARS lipsticks also landed in top 10 slots, as did one from Stargazer.
The findings exacerbate an ongoing disagreement between the FDA and the Campaign for Safe Cosmetics, a consumer group that's been pushing the government for years to set limits for lead levels in lipsticks.

The FDA has resisted, insisting that the lead levels detected in two rounds of its own testing, including the most recent one, do not pose safety risks. But the consumer group says the FDA has no scientific basis for its conclusion.
Reports of lead in lipstick date to the 1990s, when test results from a commercial laboratory raised concerns. The Campaign for Safe Cosmetics tested 33 red lipsticks in 2007 and found that two-thirds of them contained lead — and that one-third of those exceeded the FDA's limit for lead in candy.
The FDA followed up with its own tests on 20 lipsticks in 2008 and then on 400 lipsticks in the most recent analysis, and found detectable levels in all the products it tested.

The 10 lipstick brands and shades that contain the most lead, according the FDA study.
1. Maybelline's Color Sensation in Pink Petal. (Lead content: 7.19 ppm)
2. L'Oreal Colour Riche in Volcanic. (Lead content: 7.00 ppm)
3. NARS Semi-Matte in Red Lizard. (Lead content: 4.93 ppm)
4. Cover Girl Queen Collection Vibrant Hues Color in Ruby Remix (Lead content: 4.92 ppm)
5. NARS Semi-Matte in Funny Face. (Lead content: 4.89)
6. L'Oreal Colour Rich in Tickled Pink. (Lead content: 4.45)
7. L'Oreal Intensely Moisturizing Lipcolor in Heroic. (Lead content: 4.41)
8. Cover Girl Continuous Color in Warm Brick. (Lead content: 4.28)
9. Maybelline Color Sensational in Mauve Me. (Lead content: 4.23)
10. Stargazer lipstick in shade ''c.'' (Lead content: 4.12)


Read more: http://www.theage.com.au/lifestyle/beauty/top-lipstick-brands-carry-highest-lead-levels-20120215-1t4t4.html#ixzz1mPpZEO5h

Tuesday, January 10, 2012

China stops unapproved stem cell treatments

January 10, 2012

BEIJING, Jan 10 — China has ordered a halt to all unapproved stem cell treatments and clinical trials, state media reported today, as Beijing seeks to rein in the largely untested stem cell therapies now on offer across the country.

The Ministry of Health has also stopped accepting new applications for stem cell programmes, a ban that will last until July and comes as China begins a one-year programme to regulate the sector better, Xinhua cited a ministry spokesman as saying.

A growing number of hospitals and specialist clinics in large cities in China have been offering stem cell therapies in recent years for treatment of diseases ranging from cancer and Alzheimer’s to spinal cord injuries, treatments that are backed by little or no scientific evidence and which are considered at best experimental.

Some of these involve large general hospitals where patients pay thousands — or even tens of thousands — of dollars for treatments that are advertised online.

The ministry spokesman said health providers could no longer charge money for experimental stem cell applications.

According to patients, doctors and relatives of patients who spoke to Reuters earlier, patients have come away with little or no improvement and a number have died. Receipts seen by Reuters indicate that one of these hospitals is run by the Chinese army.

Such treatment involving stem cell therapies is not confined to China.

Experts have raised the alarm about patients turning up at clinics and hospitals in Mexico, India, Turkey, Russia and elsewhere for stem cell therapies that have not undergone clinical trials and which are not recognised as standard treatment.

Last week, the United States’ Food and Drug Administration issued a warning about unproven stem cell claims.

China’s Ministry of Health was not immediately reachable for comment after the Xinhua report. — Reuters

Friday, November 18, 2011

Clinic services - updated list

NEEDLE therapy + GROWTH FACTOR therapy
Needle Therapy is a piercing method creating micro-channels on the skin by using arrays of needles to increase the absorption of Growth factor or PRP to produce collagen. (Detailed info @ http://drleng.blogspot.com/2011/10/growth-factor-therapy.html)

PRP Tissue Regeneration (using MyCells kit, For more info: http://www.my-cells.net/FAQ.htm) – for total face rejuvenation, to fill in deep lines & rebuild collagen using your own growth factors derived from your own blood.

UNIXEL FRACTIONAL CO2 LASER RESURFACING (For more info: www.drleng.blogspot.com/2009/09/unixel-fractional-co2-laser.html )
o Scars (acne, burns, surgical, traumatic)
o wrinkles & skin tightening
o melasma
o uneven skin pigmentation
o open pores

RADIOFREQUENCY skin tightening and face lifting

MESOTHERAPY facial – microdermbrasion followed by needle mesotherapy with infusion of multivitamin & hyaluronic acid & Botox cocktail

Anti-aging BIO-IDENTICAL HORMONES (BIH) - more detailed info @ http://drleng.blogspot.com/2010/06/bioidentical-hormone-replacement.html

CYNOSURE ELITE LASER (detailed info @ http://drleng.blogspot.com/2009/11/cynosure-laser-hair-removal-laserfacial.html)
- Hair removal
- LaserFACIAL for wrinkle reduction & skin tightening
- leg & facial Vein removal

BOTOX injections ( more details @ http://drleng.blogspot.com/2009/07/liquid-facelift.html)
- irons out dynamic wrinkles (frown lines, crows’ feet, undereye lines, lines around lips, Marionette lines, etc)
- brow reshaping
- face reshaping - square to slimmer jaw, calf reshaping
- “dermolift”

FILLERS
NEW!! - Teosyal Puresense - local anaesthetic is incorporated into the filler to make it an almost painless procedure
– Teosyal/Varioderm – fills out deep wrinkles & face reshaping e.g. injection to give fuller lips, fill out depressed (e.g. acne, chickenpox) scars
– Subdermal/Ultradeep – nose augmentation, fill out deep wrinkles, augment cheeks
– Mesolift – rejuvenate thin delicate skin around eyes, neck, back of hands


MICRODERMABRASION (diamond ) – resurfaces the skin, removes whiteheads & blackheads

DERMOELECTROPORATION aka needle-free mesotherapy– a non-invasive transdermal delivery system that delivers nutrients to rejuvenate the skin without trauma or needles


ELECTROSURGERY – removal of warts, moles, lumps & bumps

CRYOTHERAPY – removal of viral warts

MEDLITE laser – removal of pigmentation, tattoos and birthmarks

IPL (Intense Pulsed Light) - good for epidermal pigment removal & overall rejuvenation

Permanent HAIR REMOVAL by ELITE laser

ACNE and SCAR treatment – FCO2 laser (see above), needleabrasion, chemical reconstruction of scars, subcision

RADIANTMAX LED Blue phototherapy for acne

RADIANTMAX Red Low Level Laser therapy for skin & & hair rejuvenation (more info @ http://drleng.blogspot.com/2010/06/lasers-useful-for-promoting-hair-growth.html)

KELOID injections

HAIR REGROWTH PROGRAMME
· home use Radiantlife HRx laser (www.radiantlasercomb.com) +/- in-clinic RadiantMax laser
· Needling cum scalp infusion
· Home-use hair care formulas - Regaine, Tricoaid shampoo & solution
· Oral prescription medications
· Oral nutritional supplements – Crowning Glory


WEIGHT MANAGEMENT PROGRAMMES
– oral prescription meds (Aslene, Duromine) & supplements, food replacement
- lipolytic fat injections

VELASMOOTH "3-in-1” radiofrequency, infrared & negative pressure & tissue massage to
- Reduce cellulite
- Smoothen & firm the skin
- Reshape & contour the body
- Relieves muscle aches & pains

SKINCARE brands – various

MINERAL MAKEUP